New York City has been described as the cultural, financial, and media capital of the world, significantly influencing commerce, entertainment, research, technology, education, politics, tourism, art, fashion, and sports. Tourism is a vital industry for New York City, which has witnessed a growing combined volume of international and domestic tourists, receiving an eighth consecutive annual record of approximately 62.8 million visitors in 2017. Tourism had generated an all-time high $61.3 billion in overall economic impact for New York City in 2014, 2015. New York City's most important economic sector lies in its role as the headquarters for the U.S. financial industry, metonymously known as Wall Street.

Jersey City is the second-most populous city in the U.S. state of New Jersey, after Newark. It is the seat of Hudson County as well as the county's largest city. Jersey City is a regional employment center with over 100,000 private and public sector jobs, which creates a daytime swell in population. Many jobs are in the financial and service sectors, as well as in shipping, logistics, and retail. Jersey City's Hudson River waterfront, from Exchange Place to Newport, is known as Wall Street West and has over 13 million square feet of Class A office space. One third of the private sector jobs in the city are in the financial services sector: more than 60% are in the securities industry, 20% are in banking and 8% in insurance.

Philadelphia, colloquially Philly, is the largest city in the U.S. state of Pennsylvania, and the sixth-most populous U.S. city with a 2019 estimated population of 1,584,064. Since 1854, the city has had the same geographic boundaries as Philadelphia County, the most populous county in Pennsylvania and the urban core of the eighth-largest U.S. metropolitan statistical area, with over 6 million residents as of 2017. Philadelphia is also the economic and cultural anchor of the greater Delaware Valley, located along the lower Delaware and Schuylkill Rivers, within the Northeast megalopolis. The Delaware Valley's population of 7.2 million ranks it as the eighth-largest combined statistical area in the United States.Philadelphia is the center of economic activity in Pennsylvania with the headquarters of five Fortune 1000 companies located within city limits.

Indianapolis, colloquially known as Indy, is the state capital and most-populous city of the U.S. state of Indiana and the seat of Marion County. In 2015, the Indianapolis metropolitan area had a gross domestic product (GDP) of $134 billion. The top five industries were: finance, insurance, real estate, rental, and leasing ($30.7B), manufacturing ($30.1B), professional and business services ($14.3B), educational services, health care, and social assistance ($10.8B), and wholesale trade ($8.1B). Government, if it had been a private industry, would have ranked fifth, generating $10.2 billion. Compared to Indiana as a whole, the Indianapolis metropolitan area has a lower proportion of manufacturing jobs and a higher concentration of jobs in wholesale trade; administrative, support, and waste management; professional, scientific, and technical services; and transportation and warehousing.

Chicago, officially the City of Chicago, is the most populous city in the U.S. state of Illinois, and the third-most-populous city in the United States. At nearly 10 million people, the metropolitan area is the third most populous in the United States. The city has also been rated as having the most balanced economy in the United States, due to its high level of diversification. In 2007, Chicago was named the fourth-most important business center in the world in the MasterCard Worldwide Centers of Commerce Index. Chicago is a major world financial center, with the second-largest central business district in the United States. The city is the seat of the Federal Reserve Bank of Chicago, the Bank's Seventh District. The city has major financial and futures exchanges, including the Chicago Stock Exchange, the Chicago Board Options Exchange (CBOE), and the Chicago Mercantile Exchange (the "Merc").

Louisville is the largest city in the Commonwealth of Kentucky and the 29th most-populous city in the United States. It is one of two cities in Kentucky designated as first-class. Louisville is the historical seat and, since 2003, the nominal seat of Jefferson County, on the Indiana border. Louisville today is home to dozens of companies and organizations across several industrial classifications. However, the underpinning of the city's economy since its earliest days has been the shipping and cargo industries. Louisville's importance to the shipping industry continues today with the presence of the World-port global air-freight hub for UPS at Louisville International Airport. Its strategic location at the Falls of the Ohio, as well as its unique position in the central United States make it a practical location for the transfer of cargo along its route to other destinations.

Dallas is a city in the U.S. state of Texas and the largest city and seat of Dallas County, with portions extending into Collin, Denton, Kaufman and Rockwall counties. With an estimated 2019 population of 1,343,573, it is the ninth most-populous city in the U.S. and the third-largest in Texas after San Antonio and Houston. Located in North Texas, the city of Dallas is the main core of the largest metropolitan area in the Southern United States and the largest inland metropolitan area in the U.S. that lacks any navigable link to the sea. It is the most populous city in the Dallas–Fort Worth metroplex, the fourth-largest metropolitan area in the country at 7.5 million people. The Dallas–Fort Worth area has one of the largest concentrations of corporate headquarters for publicly traded companies in the United States.

Boston is the capital and most populous city of the Commonwealth of Massachusetts in the United States, and the 21st most populous city in the United States. The city proper covers 49 square miles with an estimated population of 692,600 in 2019. The city is the economic and cultural anchor of a substantially larger metropolitan area known as Greater Boston, a metropolitan statistical area (MSA) home to a census-estimated 4.8 million people in 2016 and ranking as the tenth-largest MSA in the country. A global city, Boston is placed among the top 30 most economically powerful cities in the world. Encompassing $363 billion, the Greater Boston metropolitan area has the sixth-largest economy in the country and 12th-largest in the world.Tourism also composes a large part of Boston's economy.

Pittsburgh is a city in the state of Pennsylvania in the United States, and is the county seat of Allegheny County. A population of about 300,286 (2019) residents live within the city limits, making it the 66th-largest city in the U.S. and the second-most populous city in Pennsylvania behind Philadelphia. The Pittsburgh metropolitan area is the anchor of Western Pennsylvania; its population of 2,324,743 is the largest in both the Ohio Valley and Appalachia, the second-largest in Pennsylvania, and the 27th-largest in the U.S.Pittsburgh has adapted since the collapse of its century-long steel and electronics industries. The region has shifted to high technology, robotics, health care, nuclear engineering, tourism, biomedical technology, finance, education, and services. Annual payroll of the region's technology industries, when taken in aggregate, exceeded $10.8 billion in 2007.

Overland Park is the second-most populous city in the U.S. state of Kansas. Located in Johnson County, it is a suburb of Kansas City, Missouri and the second-most populous city in the Kansas City metropolitan area. As of the 2010 census, the city population was 173,372, growing to 195,494 by 2019. It was the home to the Sprint World Headquarters Campus until the company’s merger with T-Mobile was complete. The service sector constitutes most of the local economy. Health care, retail trade, professional and technical services, finance and insurance, and information technology are the city's five largest industries. Companies with headquarters in the city include Sprint Corporation, YRC Worldwide, Black & Veatch, Waddell & Reed, Ferrellgas, Ash Grove Cement Company, and Compass Minerals. The city seeks to attract technology companies in particular.

Portland is the most populous city in the U.S. state of Maine and the seat of Cumberland County. Portland's population was 66,215 as of 2019. The Greater Portland metropolitan area is home to over half a million people, the 105th-largest metropolitan area in the United States. Portland's economy relies mostly on the service sector and tourism. The Old Port district is known for its 19th-century architecture and nightlife. Marine industry still plays an important role in the city's economy, with an active waterfront that supports fishing and commercial shipping. The Port of Portland is the largest tonnage seaport in New England. In January 2020 Portland was announced to be the location of a new research institute that will focus on the application of artificial intelligence and machine learning. Northeastern University was selected by technology entrepreneur David Roux to lead the institute that will include programs that will allow graduate student research.

Maple Grove is a city in Hennepin County, Minnesota, United States. The population was 61,567 at the 2010 census but has been growing rapidly since then, as 2019 US census estimates rank Maple Grove as Minnesota's eighth largest city with 72,622 residents. Maple Grove serves as the retail, cultural and medical center of the northwest region of the Minneapolis–Saint Paul metropolitan area. One of the Twin Cities' largest shopping centers, The Shoppes at Arbor Lakes, is located in Maple Grove. Additionally, Maple Grove is also home to the Hindu Temple of Minnesota, which is the largest Hindu temple in the state. Maple Grove is home to a regional Boston Scientific research, development and manufacturing facility, employing over 3,000 people. Other major employers include the Independent School District 279 and the city of Maple Grove. Maple Grove is home to more retail than nearly any other city in the state, second only to Bloomington, the home of the Mall of America.

Wilmington is a port city and the county seat of New Hanover County in coastal southeastern North Carolina, United States. With a population of 123,744 in 2019, it is the eighth most populous city in the state. Wilmington is the principal city of the Wilmington Metropolitan Statistical Area, a metropolitan area that includes New Hanover and Pender counties in southeastern North Carolina. Wilmington's industrial base includes electrical, medical, electronic and telecommunications equipment; clothing and apparel; food processing; paper products; nuclear fuel; and pharmaceuticals. Wilmington is part of North Carolina's Research coast, adjacent to the Research Triangle Park in Durham, NC. Also important to Wilmington's economy is tourism due to its close proximity to the ocean and vibrant nightlife. Located on the Cape Fear River, which flows into the Atlantic Ocean, Wilmington is a sizable seaport, including private marine terminals and the North Carolina State Ports Authority's Port of Wilmington. Wilmington is home to the Greater Wilmington Chamber of Commerce, the oldest Chamber in North Carolina, organized in 1853. Companies with their headquarters in Wilmington include Live Oak Bank and HomeInsurance.com.

Baltimore is the most populous city in the U.S. state of Maryland, as well as the 30th most populous city in the United States, with a population of 593,490 in 2019. Baltimore is the largest independent city in the country and was designated as such by the Constitution of Maryland in 1851. As of 2017, the population of the Baltimore metropolitan area was estimated to be just under 2.802 million, making it the 21st largest metropolitan area in the country. Baltimore is located about 40 miles (64 km) northeast of Washington, D.C., making it a principal city in the Washington–Baltimore combined statistical area (CSA), the fourth-largest CSA in the nation, with a calculated 2018 population of 9,797,063. The center of international commerce for the region is the World Trade Center Baltimore. It houses the Maryland Port Administration and U.S. headquarters for major shipping lines. Baltimore is ranked 9th for total dollar value of cargo and 13th for cargo tonnage for all U.S. ports. Baltimore's history and attractions have allowed the city to become a popular tourist destination on the East Coast. In 2014, the city hosted 24.5 million visitors, who spent $5.2 billion.

St. Louis is the second-largest city in Missouri, and sits on the western bank of the Mississippi River, which forms the state line between Illinois and Missouri. The Missouri River merges with the Mississippi River 15 river miles north of Downtown St. Louis, forming the fourth-longest river system in the world. In 2019, the estimated population of St. Louis City was 300,576, and of the bi-state metropolitan area, 2,804,724. Greater St. Louis is the largest metropolitan area in Missouri, second-largest in Illinois, seventh-largest in the Great Lakes Megalopolis, and the 22nd-largest in the United States. As of 2018, the St. Louis Metropolitan Area is home to ten Fortune 500 companies, the 7th-most among U.S. cities. They include Express Scripts, Emerson Electric, Monsanto, Reinsurance Group of America, Centene, Graybar Electric, and Edward Jones Investments

Medford is a city in, and the county seat of, Jackson County, Oregon, in the United States. As of July 1, 2019, the city had a total population of 83,072 and a metropolitan area population of 217,479, making the Medford MSA the fourth largest metro area in Oregon. The city was named in 1883 by David Loring, civil engineer and right-of-way agent for the Oregon and California Railroad, after Medford, Massachusetts, which was near Loring's hometown of Concord, Massachusetts. Medford is near the middle ford of Bear Creek. Medford's economy is driven primarily by the health care industry. The two major medical centers in the city, Asante Rogue Regional Medical Center and Providence Medford Medical Center, employ over 2,000 people. In the past, Medford's economy was fueled by agriculture (pears, peaches, viticulture grapes) and timber products.

Chattanooga is a city in and the county seat of Hamilton County, Tennessee, along the Tennessee River bordering Georgia. With an estimated population of 182,799 in 2019, it is the fourth-largest city in Tennessee and one of the two principal cities of East Tennessee, along with Knoxville. The city anchors the Chattanooga metropolitan area, the fourth largest metropolitan statistical area in Tennessee, as well as a larger three-state area that includes Southeast Tennessee, Northwest Georgia, and Northeast Alabama. Served by multiple railroads and Interstate highways, Chattanooga is a transit hub. Chattanooga lies 118 miles (190 km) northwest of Atlanta, Georgia, 112 miles (180 km) southwest of Knoxville, Tennessee, 134 miles (216 km) southeast of Nashville, Tennessee, 102 miles (164 km) east-northeast of Huntsville, Alabama, and 147 miles (237 km) northeast of Birmingham, Alabama. Chattanooga's economy includes a diversified and growing mix of manufacturing and service industries.

Salt Lake City is the capital and most populous city of the U.S. state of Utah, as well as the seat of Salt Lake County, the most populous county in Utah. With an estimated population of 200,567 in 2019, the city is the core of the Salt Lake City metropolitan area, which has a population of 1,222,540 (2018 estimate). Salt Lake City is further situated within a larger metropolis known as the Salt Lake City–Ogden–Provo Combined Statistical Area, a corridor of contiguous urban and suburban development stretched along a 120-mile (190 km) segment of the Wasatch Front, comprising a population of 2,606,548 (as of 2018 estimates), making it currently the 22nd largest in the nation. It is the larger of only two major urban areas located within the Great Basin (the other being Reno, Nevada). It is categorized as a "Gamma−" global city, according to the Globalization and World Cities Research Network. Salt Lake City is home to two Fortune 1000 companies, Zions Bancorporation and Questar Corporation.

Atlanta is the capital and most populous city of the U.S. state of Georgia. With an estimated 2019 population of 506,811, it is also the 37th most populous city in the United States. The city serves as the cultural and economic center of the Atlanta metropolitan area, home to more than 6 million people and the ninth-largest metropolitan area in the nation. Atlanta is the seat of Fulton County, the most populous county in Georgia. Portions of the city extend eastward into neighboring DeKalb County. The city is situated among the foothills of the Appalachian Mountains and has the highest elevation among major cities east of the Mississippi River. With a GDP of $385 billion,[22] the Atlanta metropolitan area's economy is the tenth-largest in the country and among the top 20-largest in the world. Corporate operations play a major role in Atlanta's economy, as the city claims the nation's third-largest concentration of Fortune 500 companies. Information technology (IT) has become an increasingly important part of Atlanta's economic output, earning the city the nickname the "Silicon peach".

Los Angeles officially the City of Los Angeles and often known by its initials L.A., is the largest city in California. With an estimated population of nearly four million people, it is the second most populous city in the United States (after New York City) and the third most populous city in North America (after Mexico City and New York City). Los Angeles is known for its Mediterranean climate, ethnic diversity, Hollywood entertainment industry, and its sprawling metropolis. Los Angeles has a diverse economy and hosts businesses in a broad range of professional and cultural fields. It also has the busiest container port in the Americas. The economy of Los Angeles is driven by international trade, entertainment (television, motion pictures, video games, music recording, and production), aerospace, technology, petroleum, fashion, apparel, and tourism.[citation needed] Other significant industries include finance, telecommunications, law, healthcare, and transportation. Los Angeles is the largest manufacturing center in the United States.

Houston is the most populous city in the U.S. state of Texas, fourth-most populous city in the United States, most populous city in the Southern United States, as well as the sixth-most populous in North America, with an estimated 2019 population of 2,320,268. Located in Southeast Texas near Galveston Bay and the Gulf of Mexico, it is the seat of Harris County and the principal city of the Greater Houston metropolitan area, which is the fifth-most populous metropolitan statistical area in the United States and the second-most populous in Texas after the Dallas–Fort Worth metroplex, with a population of 7,066,141 in 2019. Houston is the southeast anchor of the greater megaregion known as the Texas Triangle. Houston is recognized worldwide for its energy industry—particularly for oil and natural gas—as well as for biomedical research and aeronautics. Renewable energy sources—wind and solar—are also growing economic bases in the city. The city and area have also been growing centers for technology